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Clinical Usefulness of Perioperative C-reactive Protein/Albumin Ratio in Patients With Intrahepatic Cholangiocarcinoma: A Retrospective Single Institutional Study.
- Source :
-
Anticancer research [Anticancer Res] 2019 May; Vol. 39 (5), pp. 2641-2646. - Publication Year :
- 2019
-
Abstract
- Background/aim: Prognoses of patients with cancer can be predicted on the basis of preoperative nutrition- or inflammation-based scores; however, predicting the prognostic impact of undergoing surgery remains challenging. In this study, we investigated the usefulness of the perioperative C-reactive protein/albumin (CRP/Alb) ratio in patients with intrahepatic cholangiocarcinoma (ICC).<br />Patients and Methods: We retrospectively investigated 80 patients who had undergone curative resection of primary ICC between April 2002 and December 2017. We identified the time at which perioperative CRP/Alb ratio most influences the prognosis, and investigated the correlations among the perioperative CRP/Alb ratio, clinicopathological features and patient outcomes.<br />Results: The only perioperative CRP/Alb ratios significantly associated with shorter overall survival (OS) was a high CRP/Alb ratio on POD14. High CRP/Alb ratio on POD 14 was significantly associated with older age, male sex, and the presence of postoperative complications. Finally, a high CRP/Alb ratio at POD 14 was an independent prognostic factor for poor OS.<br />Conclusion: CRP/Alb ratio on POD 14 may be a useful prognostic factor in patients with ICC who have undergone curative resections.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Cholangiocarcinoma pathology
Cholangiocarcinoma surgery
Disease-Free Survival
Female
Humans
Inflammation pathology
Kaplan-Meier Estimate
Male
Middle Aged
Perioperative Period
Prognosis
Retrospective Studies
C-Reactive Protein metabolism
Cholangiocarcinoma blood
Inflammation blood
Serum Albumin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 39
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 31092463
- Full Text :
- https://doi.org/10.21873/anticanres.13388