Fluorine-Containing Drugs Approved by the FDA in 2018.

Authors :: Mei H
Han J
Fustero S
Medio-Simon M
Sedgwick DM
Santi C
Ruzziconi R
Soloshonok VA
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2019 Sep 12; Vol. 25 (51), pp. 11797-11819. Date of Electronic Publication: 2019 Jul 08.
Publication Year :: 2019
Abstract: Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine-containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF <subscript>3</subscript> , as well as aliphatic (CF <subscript>2</subscript> ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.<br /> (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)