Back to Search
Start Over
Tissue sodium content in patients with type 2 diabetes mellitus.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2019 Jul; Vol. 33 (7), pp. 485-489. Date of Electronic Publication: 2019 Apr 16. - Publication Year :
- 2019
-
Abstract
- Background: Tissue sodium content by <superscript>23</superscript> Na magnetic resonance imaging (MRI) has been found to be increased in arterial hypertension. We analyzed whether tissue sodium content is increased in patients with type-2 diabetes (T2DM).<br />Methods: Patients with T2DM were compared to those with primary hypertension. Patients with T2DM were off any antidiabetic and hypertensive patients off any antihypertensive therapy for at least 4 weeks. Skin and muscle sodium content was assessed non-invasively with a 3.0 T clinical MRI system (Magnetom Verio, Siemens Health Care, Erlangen, Germany) in each patient.<br />Results: In patients with T2DM (N = 59) we observed significantly greater muscle sodium content (diabetes: 20.6 ± 3.5 vs hypertension: 16.3 ± 2.5 mmol/l, p < 0.001) and skin sodium content (diabetes: 24.5 ± 7.2 vs hypertension: 20.6 ± 5.7 mmol/l, p = 0.01) than in those with primary hypertension (N = 33). When potential confounders (age, body mass index, gender, systolic and diastolic blood pressure, estimated glomerular filtration rate) were entered in a covariance analysis, both skin sodium content (p = 0.037) and muscle sodium content (p < 0.001) were still clearly elevated.<br />Conclusion: Patients with T2DM have greater skin and muscle sodium content. These are the first known data to demonstrate increased tissue sodium content in patients with T2DM, measured by <superscript>23</superscript> Na magnetic resonance imaging. Since tissue sodium content is related to organ damage, therapeutic intervention should aim at reducing tissue sodium content.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Case-Control Studies
Diabetes Mellitus, Type 2 diagnosis
Female
Germany
Glomerular Filtration Rate
Humans
Hypertension metabolism
Magnetic Resonance Imaging methods
Male
Middle Aged
Muscles chemistry
Sex Factors
Skin chemistry
Sodium analysis
Sodium Isotopes analysis
Tissue Distribution
Diabetes Mellitus, Type 2 metabolism
Muscles metabolism
Skin metabolism
Sodium metabolism
Sodium Isotopes pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 33
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 31101486
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2019.04.006