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Tissue sodium content in patients with type 2 diabetes mellitus.

Authors :
Kannenkeril D
Karg MV
Bosch A
Ott C
Linz P
Nagel AM
Uder M
Schmieder RE
Source :
Journal of diabetes and its complications [J Diabetes Complications] 2019 Jul; Vol. 33 (7), pp. 485-489. Date of Electronic Publication: 2019 Apr 16.
Publication Year :
2019

Abstract

Background: Tissue sodium content by <superscript>23</superscript> Na magnetic resonance imaging (MRI) has been found to be increased in arterial hypertension. We analyzed whether tissue sodium content is increased in patients with type-2 diabetes (T2DM).<br />Methods: Patients with T2DM were compared to those with primary hypertension. Patients with T2DM were off any antidiabetic and hypertensive patients off any antihypertensive therapy for at least 4 weeks. Skin and muscle sodium content was assessed non-invasively with a 3.0 T clinical MRI system (Magnetom Verio, Siemens Health Care, Erlangen, Germany) in each patient.<br />Results: In patients with T2DM (N = 59) we observed significantly greater muscle sodium content (diabetes: 20.6 ± 3.5 vs hypertension: 16.3 ± 2.5 mmol/l, p < 0.001) and skin sodium content (diabetes: 24.5 ± 7.2 vs hypertension: 20.6 ± 5.7 mmol/l, p = 0.01) than in those with primary hypertension (N = 33). When potential confounders (age, body mass index, gender, systolic and diastolic blood pressure, estimated glomerular filtration rate) were entered in a covariance analysis, both skin sodium content (p = 0.037) and muscle sodium content (p < 0.001) were still clearly elevated.<br />Conclusion: Patients with T2DM have greater skin and muscle sodium content. These are the first known data to demonstrate increased tissue sodium content in patients with T2DM, measured by <superscript>23</superscript> Na magnetic resonance imaging. Since tissue sodium content is related to organ damage, therapeutic intervention should aim at reducing tissue sodium content.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1873-460X
Volume :
33
Issue :
7
Database :
MEDLINE
Journal :
Journal of diabetes and its complications
Publication Type :
Academic Journal
Accession number :
31101486
Full Text :
https://doi.org/10.1016/j.jdiacomp.2019.04.006