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Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence.
- Source :
-
Neurochemical research [Neurochem Res] 2019 Aug; Vol. 44 (8), pp. 1818-1829. Date of Electronic Publication: 2019 May 17. - Publication Year :
- 2019
-
Abstract
- Excessive physical exercise (overtraining; OT) increases oxidative stress and induces damage in multiple organs including the brain, especially the hippocampus that plays an important role in learning and memory. Silibinin, a natural flavonoid derived from milk thistle of Silybum marianum, has been reported to exert neuroprotective effect. In this study, rats were subjected to overtraining exercise, and the protective effects of silibinin were investigated in these models. Morris water maze and novel object recognition tests showed that silibinin significantly attenuated memory defects in overtrained rats. At the same time, the results of Nissl, TUNEL and SA-β-gal staining showed that silibinin reversed neuronal loss caused by apoptosis, and delayed cell senescence of the hippocampus in the overtrained rats, respectively. In addition, silibinin decreased malondialdehyde (MDA) levels which is associated with reactive oxygen species (ROS) generation. Silibinin prevented impairment of learning and memory caused by excessive physical exercise in rats, accompanied by reduced apoptosis and senescence in hippocampus cells.
- Subjects :
- Animals
Catalase metabolism
Hippocampus pathology
Male
Malondialdehyde metabolism
Oxidative Stress drug effects
Physical Conditioning, Animal adverse effects
Rats, Sprague-Dawley
Superoxide Dismutase metabolism
Aging drug effects
Apoptosis drug effects
Maze Learning drug effects
Memory Disorders drug therapy
Neuroprotective Agents therapeutic use
Silybin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6903
- Volume :
- 44
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Neurochemical research
- Publication Type :
- Academic Journal
- Accession number :
- 31102026
- Full Text :
- https://doi.org/10.1007/s11064-019-02816-2