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Seasonally varied cytotoxicity of organic components in PM 2.5 from urban and industrial areas of a Chinese megacity.
- Source :
-
Chemosphere [Chemosphere] 2019 Sep; Vol. 230, pp. 424-431. Date of Electronic Publication: 2019 May 08. - Publication Year :
- 2019
-
Abstract
- The atmospheric fine particulate matters (PM <subscript>2.5</subscript> ) induce significant negative effects on human health, such as in the form of oxidative stress and pro-inflammatory response. Organic pollutants are important harmful and toxic compositions in PM <subscript>2.5</subscript> , risks of which usually show temporal and spatial variations. To investigate the toxic effects of airborne organic pollutants on human lung epithelial cells A549, the PM <subscript>2.5</subscript> samples were collected monthly from both urban and industrial areas during a whole year in Nanjing, eastern China. After exposure to organic components extracted from these PM <subscript>2.5</subscript> , the cell viability, lactate dehydrogenase content, oxidative stress index level and inflammatory factor expression level were measured. Supported by the concentrations of polycyclic aromatic hydrocarbons (PAHs) and n-alkanes, results showed that, organic components of PM <subscript>2.5</subscript> from cold season (winter and spring) typically influenced cell membrane, cell oxidation and inflammatory damage, while the urban samples of warm season (summer and autumn) impacted cell viability more prominently. Spatially, the toxicity of samples from industrial sources was generally stronger than that from urban source, but urban samples induced much stronger damage to cell membranes than industrial one. The correlations between the PAHs, n-alkanes contents and toxicity parameters indicated that, the airborne organic components derived from motor vehicle exhaust and coal combustion were possibly the key toxic sources.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- A549 Cells
Air Pollutants analysis
Alkanes analysis
Cell Survival drug effects
China
Cities
Climate
Humans
Industry
Particulate Matter analysis
Polycyclic Aromatic Hydrocarbons analysis
Seasons
Vehicle Emissions analysis
Air Pollutants toxicity
Alkanes toxicity
Environmental Monitoring methods
Particulate Matter toxicity
Polycyclic Aromatic Hydrocarbons toxicity
Vehicle Emissions toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1298
- Volume :
- 230
- Database :
- MEDLINE
- Journal :
- Chemosphere
- Publication Type :
- Academic Journal
- Accession number :
- 31112865
- Full Text :
- https://doi.org/10.1016/j.chemosphere.2019.04.226