In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe.

Authors :: Zhou Y
Li P
Fan N
Wang X
Liu X
Wu L
Zhang W
Zhang W
Ma C
Tang B
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Jun 06; Vol. 55 (47), pp. 6767-6770.
Publication Year :: 2019
Abstract: We developed a new two-photon fluorescent probe (PX-1) with high selectivity and sensitivity for detecting peroxisomal peroxynitrite. PX-1 was successfully applied to in situ imaging of peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride.

Subjects :: Amino Acid Sequence
Animals
Carbon Tetrachloride toxicity
Cell Line, Tumor
Chemical and Drug Induced Liver Injury etiology
Humans
Liver metabolism
Mice
Microscopy, Fluorescence, Multiphoton
Peroxisomes metabolism
Chemical and Drug Induced Liver Injury pathology
Fluorescent Dyes chemistry
Liver chemistry
Peroxisomes chemistry
Peroxynitrous Acid chemistry

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