A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata .

A new dimeric quaternary protoberberine alkaloid, bispalmatrubine ( 1 ), and thirteen known compounds ( 2 - 14 ) were purified from the tubers of Tinospora dentata . Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N -formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.