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Remodelling in atrial fibrillation: the impact of amiodarone.
- Source :
-
Cardiovascular journal of Africa [Cardiovasc J Afr] 2019 May/Jun 23; Vol. 30 (3), pp. 174-180. Date of Electronic Publication: 2019 Mar 27. - Publication Year :
- 2019
-
Abstract
- Atrial fibrillation (AF) is a common heart rhythm disorder with a prevalence of up to 2.9% in the general population. Its mechanism involves a particular electrophysiological profile as well as structural and biohumoral changes that are often irreversible. With the recent advances in pharmacology, amiodarone remains the cornerstone for the treatment of AF. Although it is one of the most controversial anti-arrhythmic agents due to the multitude of side effects, it is further recognised as the most effective drug available for the conversion and maintenance of sinus rhythm in the case of significant left ventricular dysfunction or severe aortic stenosis. This quality is provided by its multivalent profile, with a complex electrophysiological activity overlapped with an anti-inflammatory and vasodilatory effect. This review aims to outline the main structural and functional changes in AF and the multisite impact of amiodarone on its treatment.
- Subjects :
- Action Potentials
Amiodarone adverse effects
Animals
Anti-Arrhythmia Agents adverse effects
Atrial Fibrillation metabolism
Atrial Fibrillation physiopathology
Autonomic Nervous System drug effects
Autonomic Nervous System physiopathology
Heart Atria innervation
Heart Atria metabolism
Heart Atria physiopathology
Humans
Inflammation Mediators metabolism
Signal Transduction
Treatment Outcome
Amiodarone therapeutic use
Anti-Arrhythmia Agents therapeutic use
Atrial Fibrillation drug therapy
Atrial Remodeling drug effects
Heart Atria drug effects
Heart Rate drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1680-0745
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cardiovascular journal of Africa
- Publication Type :
- Academic Journal
- Accession number :
- 31140543
- Full Text :
- https://doi.org/10.5830/CVJA-2019-012