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Role of thyroid dysimmunity and thyroid hormones in endometriosis.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jun 11; Vol. 116 (24), pp. 11894-11899. Date of Electronic Publication: 2019 May 29. - Publication Year :
- 2019
-
Abstract
- Endometriosis is characterized by the presence of ectopic endometrial cells outside the uterine cavity. Thyroid autoimmunity has been associated with endometriosis. This work investigated the potential pathophysiological link between endometriosis and thyroid disorders. Transcripts and proteins involved in thyroid metabolism are dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium to triiodothyronine (T3) action and local accumulation of thyroxine (T4). Thyroid-stimulating hormone (TSH) acts as a proliferative and prooxidative hormone on all endometria of endometriosis patients and controls, whereas T3 and T4 act to specifically increase ectopic endometrial cell proliferation and reactive oxygen species (ROS) production. Mouse studies confirmed the data gained in vitro since endometriotic implants were found to be bigger when thyroid hormones increased. A retrospective analysis of endometriosis patients with or without a thyroid disorder revealed an increased chronic pelvic pain and disease score in endometriotic patients with a thyroid disorder.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Animals
Cell Proliferation physiology
Endometrium metabolism
Female
Humans
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Reactive Oxygen Species metabolism
Retrospective Studies
Thyrotropin metabolism
Thyroxine metabolism
Triiodothyronine metabolism
Endometriosis metabolism
Thyroid Gland metabolism
Thyroid Hormones metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 116
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 31142643
- Full Text :
- https://doi.org/10.1073/pnas.1820469116