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Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations.
- Source :
-
Scientific reports [Sci Rep] 2019 May 29; Vol. 9 (1), pp. 8002. Date of Electronic Publication: 2019 May 29. - Publication Year :
- 2019
-
Abstract
- Tuberculosis (TB) is a chronic inflammatory disease caused by Mycobacterium tuberculosis infection which causes tremendous morbidity and mortality worldwide. Clinical presentation of TB patients is very diverse and disease heterogeneity is associated with changes in biomarker signatures. Here, we compared at the molecular level the extent of individual inflammatory perturbation of plasma protein and lipid mediators associated with TB in patients in China versus India. We performed a cross-sectional study analyzing the overall degree of inflammatory perturbation in treatment-naïve pulmonary TB patients and uninfected individuals from India (TB: n = 97, healthy: n = 20) and China (TB: n = 100, healthy: n = 11). We employed the molecular degree of perturbation (MDP) adapted to plasma biomarkers to examine the overall changes in inflammation between these countries. M. tuberculosis infection caused a significant degree of molecular perturbation in patients from both countries, with higher perturbation detected in India. Interestingly, there were differences in biomarker perturbation patterns and the overall degree of inflammation. Patients with severe TB exhibited increased MDP values and Indian patients with this condition exhibited even higher degree of perturbation compared to Chinese patients. Network analyses identified IFN-α, IFN-β, IL-1RI and TNF-α as combined biomarkers that account for the overall molecular perturbation in the entire study population. Our results delineate the magnitude of the systemic inflammatory perturbation in pulmonary TB and reveal qualitative changes in inflammatory profiles between two countries with high disease prevalence.
- Subjects :
- Adult
Blood Proteins genetics
China epidemiology
Cytokines blood
Female
Humans
India epidemiology
Inflammation blood
Inflammation microbiology
Inflammation pathology
Interferon-gamma blood
Latent Tuberculosis blood
Latent Tuberculosis microbiology
Latent Tuberculosis pathology
Lipids blood
Male
Mycobacterium tuberculosis pathogenicity
Tuberculosis, Pulmonary blood
Tuberculosis, Pulmonary microbiology
Tuberculosis, Pulmonary pathology
Tumor Necrosis Factor-alpha blood
Biomarkers blood
Inflammation epidemiology
Latent Tuberculosis epidemiology
Tuberculosis, Pulmonary epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 31142816
- Full Text :
- https://doi.org/10.1038/s41598-019-44513-8