Raman study of impurity influence on active center in artemisinin.

Authors :: Hou HY
Yang X
Mao ZL
Yao XY
Chen XB
Source :: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2019 Oct 05; Vol. 221, pp. 117206. Date of Electronic Publication: 2019 May 27.
Publication Year :: 2019
Abstract: The unusual endoperoxide bridge is believed to be the active center for artemisinin activations. Our Raman study indicated that the active center endoperoxide bridge is more significantly influenced by impurity than other parts in artemisinin molecule. This phenomenon provides a Raman spectroscopy method for quantitative measurement of impurity content basing on the relative intensity ratio analysis of characteristic vibrational modes. The proposed Raman method can be a good alternative to high performance liquid chromatography, which is a commonly applied technique for measuring impurity content. Also, the Raman method can provide additional information of impurity homogeneity. In addition, Raman imaging is presented for easy visualization of impurity content and homogeneity in artemisinin simultaneously.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Subjects :: Artemisinins analysis
Image Processing, Computer-Assisted
Artemisinins chemistry
Spectrum Analysis, Raman methods

Language :: English
ISSN :: 1873-3557
Volume :: 221
Database :: MEDLINE
Journal :: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Publication Type :: Academic Journal
Accession number :: 31154240
Full Text :: https://doi.org/10.1016/j.saa.2019.117206