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Gravitational Influence on Intraocular Pressure: Implications for Spaceflight and Disease.
- Source :
-
Journal of glaucoma [J Glaucoma] 2019 Aug; Vol. 28 (8), pp. 756-764. - Publication Year :
- 2019
-
Abstract
- Spaceflight-associated neuro-ocular syndrome (SANS) describes a series of morphologic and functional ocular changes in astronauts first reported by Mader and colleagues in 2011. SANS is currently clinically defined by the development of optic disc edema during prolonged exposure to the weightless (microgravity) environment, which currently occurs on International Space Station (ISS). However, as improvements in our understanding of the ocular changes emerge, the definition of SANS is expected to evolve. Other ocular SANS signs that arise during and after ISS missions include hyperopic shifts, globe flattening, choroidal/retinal folds, and cotton wool spots. Over the last 10 years, ~1 in 3 astronauts flying long-duration ISS missions have presented with ≥1 of these ocular findings. Commensurate with research that combines disparate specialties (vision biology and spaceflight medicine), lessons from SANS investigations may also yield insight into ground-based ocular disorders, such as glaucomatous optic neuropathy that may have the potential to lessen the burden of this irreversible cause of vision loss on Earth.
- Subjects :
- Astronauts
Glaucoma etiology
Glaucoma physiopathology
Humans
Optic Nerve Diseases etiology
Optic Nerve Diseases physiopathology
Papilledema etiology
Space Flight
Syndrome
Vision Disorders etiology
Vision Disorders physiopathology
Gravitation
Intraocular Pressure physiology
Weightlessness adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1536-481X
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of glaucoma
- Publication Type :
- Academic Journal
- Accession number :
- 31162175
- Full Text :
- https://doi.org/10.1097/IJG.0000000000001293