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Cascade of immunologic adverse events related to pembrolizumab treatment.

Authors :
Dhenin A
Samartzi V
Lejeune S
Seront E
Source :
BMJ case reports [BMJ Case Rep] 2019 Jun 04; Vol. 12 (6). Date of Electronic Publication: 2019 Jun 04.
Publication Year :
2019

Abstract

Immune checkpoint inhibitors, such as pembrolizumab, have significantly improved cancer patient outcome. Toxicities are usually moderate and manageable. However, some adverse events, if not early recognised, could be life-threatening. We report a patient with non-small cell lung cancer who received treatment with pembrolizumab and developed multiple immune-related adverse events both during and after completing treatment, including rash, pericarditis, colitis and myasthenia gravis.<br />Competing Interests: Competing interests: None declared.<br /> (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)

Details

Language :
English
ISSN :
1757-790X
Volume :
12
Issue :
6
Database :
MEDLINE
Journal :
BMJ case reports
Publication Type :
Academic Journal
Accession number :
31167767
Full Text :
https://doi.org/10.1136/bcr-2018-229149