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Cascade of immunologic adverse events related to pembrolizumab treatment.
- Source :
-
BMJ case reports [BMJ Case Rep] 2019 Jun 04; Vol. 12 (6). Date of Electronic Publication: 2019 Jun 04. - Publication Year :
- 2019
-
Abstract
- Immune checkpoint inhibitors, such as pembrolizumab, have significantly improved cancer patient outcome. Toxicities are usually moderate and manageable. However, some adverse events, if not early recognised, could be life-threatening. We report a patient with non-small cell lung cancer who received treatment with pembrolizumab and developed multiple immune-related adverse events both during and after completing treatment, including rash, pericarditis, colitis and myasthenia gravis.<br />Competing Interests: Competing interests: None declared.<br /> (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Aged
Antibodies, Monoclonal, Humanized administration & dosage
Antibodies, Monoclonal, Humanized therapeutic use
Antineoplastic Agents, Immunological administration & dosage
Antineoplastic Agents, Immunological therapeutic use
Colitis chemically induced
Colitis drug therapy
Exanthema chemically induced
Exanthema drug therapy
Female
Humans
Lung Neoplasms pathology
Myasthenia Gravis chemically induced
Myasthenia Gravis drug therapy
Pericarditis chemically induced
Pericarditis drug therapy
Plasmapheresis methods
Treatment Outcome
Antibodies, Monoclonal, Humanized adverse effects
Antineoplastic Agents, Immunological adverse effects
Carcinoma, Non-Small-Cell Lung drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 12
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 31167767
- Full Text :
- https://doi.org/10.1136/bcr-2018-229149