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Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice.

Authors :
Adu-Frimpong M
Qiuyu W
Firempong CK
Mukhtar YM
Yang Q
Omari-Siaw E
Lijun Z
Xu X
Yu J
Source :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2019 Aug; Vol. 71 (8), pp. 1324-1338. Date of Electronic Publication: 2019 Jun 05.
Publication Year :
2019

Abstract

Objectives: Cuminaldehyde self-emulsified nanoemulsion (CuA-SEN) was prepared and optimised to improve its oral bioavailability and antihepatotoxicity.<br />Methods: Cuminaldehyde self-emulsified nanoemulsion was developed through the self-nanoemulsification method using Box-Behnken Design (BBD) tool while appropriate physicochemical indices were evaluated. The optimised CuA-SEN was characterised via droplet size (DS), morphology, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency, in-vitro release, and pharmacokinetic studies while its antihepatotoxicity was evaluated.<br />Key Findings: Cuminaldehyde self-emulsified nanoemulsion with acceptable characteristics (mean DS-48.83 ± 1.06 nm; PDI-0.232 ± 0.140; ZP-29.92 ± 1.66 mV; EE-91.51 ± 0.44%; and drug-loading capacity (DL)-9.77 ± 0.75%) was formulated. In-vitro drug release of CuA-SEN significantly increased with an oral relative bioavailability of 171.02%. Oral administration of CuA-SEN to CCl <subscript>4</subscript> -induced hepatotoxicity mice markedly increased the levels of superoxide dismutase, glutathione and catalase in serum. Also, CuA-SEN reduced the levels of tumour necrosis factor-alpha and interleukin-6 in both serum and liver tissues while aspartate aminotransferase, alanine aminotransferase and malonaldehyde levels were significantly decreased.<br />Conclusions: These findings showed that the improved bioavailability of cuminaldehyde via SEN provided an effective approach for enhancing antioxidation, anti-inflammation and antihepatotoxicity of the drug.<br /> (© 2019 Royal Pharmaceutical Society.)

Details

Language :
English
ISSN :
2042-7158
Volume :
71
Issue :
8
Database :
MEDLINE
Journal :
The Journal of pharmacy and pharmacology
Publication Type :
Academic Journal
Accession number :
31168820
Full Text :
https://doi.org/10.1111/jphp.13112