Rearranged iridal-type triterpenoids from Iris tectorum.

Authors :: Zhang CL
Wang Y
Zhao F
Liu YF
Shi GR
Chen RY
Yu DQ
Cao ZY
Source :: Fitoterapia [Fitoterapia] 2019 Sep; Vol. 137, pp. 104193. Date of Electronic Publication: 2019 Jun 05.
Publication Year :: 2019
Abstract: Three new iridal-type triterpenoids (1-3) featuring a rearranged homofarnesylside chain were isolated from the rhizomes of Iris tectorum. Compounds 2 and 3 were found to be a pair of epimers. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. A possible biosynthetic pathway for them was postulated. Moreover, the mixture of compounds 2 and 3 exhibited moderate neuroprotective activity against serum deprivation-induced PC12 cell death.<br /> (Copyright © 2019. Published by Elsevier B.V.)