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The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer.

The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer.

Authors :
Ishikawa D
Takasu C
Kashihara H
Nishi M
Tokunaga T
Higashijima J
Yoshikawa K
Yasutomo K
Shimada M
Source :
Anticancer research [Anticancer Res] 2019 Jun; Vol. 39 (6), pp. 2855-2860.
Publication Year :
2019

Abstract

Background: In a previous study, we demonstrated that deficiency of microRNA-449a (miR-449a) promoted colorectal tumorigenesis. In this study, the significance of miR-449a in the prognosis and relationship with HDAC1 in colorectal cancer was examined.<br />Materials and Methods: Seventy-two patients with colorectal cancer and 16 patients with colorectal liver metastasis who underwent surgery were included. miR-449a expression in tumor tissue of resected specimen was investigated by real-time polymerase chain reaction and histone deacetylase 1 (HDAC1) expression was examined by immunohistochemistry.<br />Results: Lymphovascular invasion and increased serum carcinoembryonic antigen levels were seen more frequent in patients with low miR-449a expression. Patients with low miR-449a expression were found to have a poorer prognosis than those with high expression. Vascular invasion, increased serum carbohydrate antigen 19-9 level and low miR-449a were associated with poorer disease-free survival. miR-449a expression was lower in metastatic liver tumor compared to primary tumor. HDAC1 positivity was higher in patients with low miR-449a.<br />Conclusion: miR-449a level might be a prognostic indicator for colorectal cancer and miR-449a might regulate HDAC1 expression.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Details

Language :
English
ISSN :
1791-7530
Volume :
39
Issue :
6
Database :
MEDLINE
Journal :
Anticancer research
Publication Type :
Academic Journal
Accession number :
31177123
Full Text :
https://doi.org/10.21873/anticanres.13414