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The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer.
The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer.
- Source :
-
Anticancer research [Anticancer Res] 2019 Jun; Vol. 39 (6), pp. 2855-2860. - Publication Year :
- 2019
-
Abstract
- Background: In a previous study, we demonstrated that deficiency of microRNA-449a (miR-449a) promoted colorectal tumorigenesis. In this study, the significance of miR-449a in the prognosis and relationship with HDAC1 in colorectal cancer was examined.<br />Materials and Methods: Seventy-two patients with colorectal cancer and 16 patients with colorectal liver metastasis who underwent surgery were included. miR-449a expression in tumor tissue of resected specimen was investigated by real-time polymerase chain reaction and histone deacetylase 1 (HDAC1) expression was examined by immunohistochemistry.<br />Results: Lymphovascular invasion and increased serum carcinoembryonic antigen levels were seen more frequent in patients with low miR-449a expression. Patients with low miR-449a expression were found to have a poorer prognosis than those with high expression. Vascular invasion, increased serum carbohydrate antigen 19-9 level and low miR-449a were associated with poorer disease-free survival. miR-449a expression was lower in metastatic liver tumor compared to primary tumor. HDAC1 positivity was higher in patients with low miR-449a.<br />Conclusion: miR-449a level might be a prognostic indicator for colorectal cancer and miR-449a might regulate HDAC1 expression.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Aged
Antigens, Tumor-Associated, Carbohydrate blood
Colorectal Neoplasms genetics
Colorectal Neoplasms metabolism
Female
Gene Expression Regulation, Neoplastic
Histone Deacetylase 1 genetics
Humans
Liver Neoplasms genetics
Liver Neoplasms metabolism
Male
Middle Aged
Neoplasm Invasiveness
Prognosis
Survival Analysis
Colorectal Neoplasms surgery
Histone Deacetylase 1 metabolism
Liver Neoplasms secondary
Liver Neoplasms surgery
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 31177123
- Full Text :
- https://doi.org/10.21873/anticanres.13414