InSe Nanosheets for Efficient NIR-II-Responsive Drug Release.

Authors :: Huang C
Sun Z
Cui H
Pan T
Geng S
Zhou W
Chu PK
Yu XF
Source :: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2019 Aug 07; Vol. 11 (31), pp. 27521-27528. Date of Electronic Publication: 2019 Jun 20.
Publication Year :: 2019
Abstract: Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.