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Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha.
- Source :
-
Molecular and cellular biochemistry [Mol Cell Biochem] 2019 Oct; Vol. 460 (1-2), pp. 81-92. Date of Electronic Publication: 2019 Jun 10. - Publication Year :
- 2019
-
Abstract
- High levels of circulating free fatty acids often trigger pancreatic β cell dysfunction during the development of type 2 diabetes. Silibinin, the main component of Silybum marianum fruit extract (silymarin), is reported to have anti-diabetic effect. This study is designed to determine the protective effect of silibinin on palmitic acid-induced damage in a rat pancreatic β-cell line, INS-1 cells. Our results demonstrate that silibinin improves cell viability, enhances insulin synthesis and secretion, and resumes normal mitochondrial function in palmitic acid-treated INS-1 cells. An accumulating body of evidence has shown that the estrogen receptors are key molecules involved in glucose and lipid metabolism. Our results suggest that silibinin upregulates ERα signaling pathway from the finding that ERα-specific inhibitors abolish the anti-lipotoxic effect of silibinin. In conclusion, these findings suggest that silibinin protects INS-1 cells against apoptosis and mitochondrial damage through upregulation of ERα pathway.
- Subjects :
- Animals
Cell Line, Tumor
Cytoprotection drug effects
Insulin-Secreting Cells drug effects
Mitochondria drug effects
Mitochondria metabolism
Protective Agents pharmacology
Rats
Silybin chemistry
Up-Regulation drug effects
Apoptosis drug effects
Estrogen Receptor alpha metabolism
Insulin-Secreting Cells metabolism
Insulin-Secreting Cells pathology
Mitochondria pathology
Palmitic Acid toxicity
Silybin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4919
- Volume :
- 460
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular and cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31183735
- Full Text :
- https://doi.org/10.1007/s11010-019-03572-1