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Macrophages and T cells in atherosclerosis: a translational perspective.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2019 Aug 01; Vol. 317 (2), pp. H375-H386. Date of Electronic Publication: 2019 Jun 14. - Publication Year :
- 2019
-
Abstract
- Atherosclerosis is now considered a chronic maladaptive inflammatory disease. The hallmark feature in both human and murine disease is atherosclerotic plaques. Macrophages and various T-cell lineages play a crucial role in atherosclerotic plaque establishment and disease progression. Humans and mice share many of the same processes that occur within atherogenesis. The various similarities enable considerable insight into disease mechanisms and those which contribute to cardiovascular complications. The apolipoprotein E-null and low-density lipoprotein receptor-null mice have served as the foundation for further immunological pathway manipulation to identify pro- and antiatherogenic pathways in attempt to reveal more novel therapeutic targets. In this review, we provide a translational perspective and discuss the roles of macrophages and various T-cell lineages in contrasting proatherosclerotic and atheroprotective settings.
- Subjects :
- Animals
Arteries metabolism
Arteries pathology
Atherosclerosis metabolism
Atherosclerosis pathology
Cell Lineage
Cytokines immunology
Cytokines metabolism
Humans
Lymphocyte Activation
Macrophage Activation
Macrophages metabolism
Phenotype
Plaque, Atherosclerotic
Signal Transduction
T-Lymphocyte Subsets metabolism
Translational Research, Biomedical
Arteries immunology
Atherosclerosis immunology
Macrophages immunology
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1539
- Volume :
- 317
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 31199186
- Full Text :
- https://doi.org/10.1152/ajpheart.00206.2019