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Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6.
- Source :
-
Molecular & cellular oncology [Mol Cell Oncol] 2019 May 07; Vol. 6 (4), pp. 1610257. Date of Electronic Publication: 2019 May 07 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Understanding and overcoming resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors will be challenging. Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine-addiction in esophageal squamous cell carcinoma. This metabolism feature makes these tumors susceptible to combined treatment with glutaminase (GLS) inhibitor and metformin even when resisting to CDK4/6 inhibitors.
Details
- Language :
- English
- ISSN :
- 2372-3556
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular & cellular oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31211239
- Full Text :
- https://doi.org/10.1080/23723556.2019.1610257