Back to Search
Start Over
Activity of Sodium Lauryl Sulfate, Rhamnolipids, and N -Acetylcysteine Against Biofilms of Five Common Pathogens.
- Source :
-
Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] 2020 Mar; Vol. 26 (3), pp. 290-299. Date of Electronic Publication: 2019 Jun 18. - Publication Year :
- 2020
-
Abstract
- Bacteria in biofilms are more resistant to antibacterial agents than bacteria in planktonic form. Hence, antibacterial agents should be able to eradicate biofilms to ensure the best outcomes. Little is known about how well many antibacterial agents can disrupt biofilms. In this study, we compared sodium lauryl sulfate (SDS), rhamnolipids (RHL), and N -acetylcysteine (NAC) for their ability to eradicate mature biofilms and inhibit new biofilm formation against Helicobacter pylori , Escherichia coli , Pseudomonas aeruginosa , Staphylococcus aureus , and Streptococcus mutans . SDS and RHL effectively inhibited formation of five bacterial biofilms in a dose-dependent manner, even at concentrations below the minimal inhibitory concentrations (MICs), suggesting that their antibiofilm activities are unrelated to their antibacterial activities. In contrast, NAC at certain concentrations promoted biofilm formation by all bacteria except P. aeruginosa , whereas at supra-MIC concentrations, it inhibited biofilm formation against the four bacteria, suggesting that its antibiofilm activity depends on its antibacterial activity. NAC was ineffective at eradicating mature H. pylori biofilms, and it actually promoted their formation at concentrations >10 mg/mL. Our results suggest that RHL is superior at eradicating biofilms of H. pylori , E. coli , and S. mutans ; SDS is more effective against S. aureus biofilms; and NAC is more effective against P. aeruginosa biofilms. Our results may help determine which antibiofilm agents are effective against certain bacterial strains and develop agents effective against specific bacterial threats.
- Subjects :
- Anti-Bacterial Agents pharmacology
Biofilms growth & development
Culture Media chemistry
Culture Media pharmacology
Escherichia coli drug effects
Escherichia coli growth & development
Helicobacter pylori growth & development
Microbial Sensitivity Tests
Plankton drug effects
Plankton growth & development
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa growth & development
Staphylococcus aureus growth & development
Streptococcus mutans drug effects
Streptococcus mutans growth & development
Acetylcysteine pharmacology
Biofilms drug effects
Glycolipids pharmacology
Helicobacter pylori drug effects
Sodium Dodecyl Sulfate pharmacology
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1931-8448
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Microbial drug resistance (Larchmont, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 31211651
- Full Text :
- https://doi.org/10.1089/mdr.2018.0385