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Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.

Authors :
Baba M
Yokoyama K
Seiriki K
Naka Y
Matsumura K
Kondo M
Yamamoto K
Hayashida M
Kasai A
Ago Y
Nagayasu K
Hayata-Takano A
Takahashi A
Yamaguchi S
Mori D
Ozaki N
Yamamoto T
Takuma K
Hashimoto R
Hashimoto H
Nakazawa T
Source :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2019 Nov; Vol. 44 (12), pp. 2125-2135. Date of Electronic Publication: 2019 Jun 19.
Publication Year :
2019

Abstract

3q29 microdeletion, a rare recurrent copy number variant (CNV), greatly confers an increased risk of psychiatric disorders, such as schizophrenia and autism spectrum disorder (ASD), as well as intellectual disability. However, disease-relevant cellular phenotypes of 3q29 deletion syndrome remain to be identified. To reveal the molecular and cellular etiology of 3q29 deletion syndrome, we generated a mouse model of human 3q29 deletion syndrome by chromosome engineering, which achieved construct validity. 3q29 deletion (Df/+) mice showed reduced body weight and brain volume and, more importantly, impaired social interaction and prepulse inhibition. Importantly, the schizophrenia-related impaired prepulse inhibition was reversed by administration of antipsychotics. These findings are reminiscent of the growth defects and neuropsychiatric behavioral phenotypes in patients with 3q29 deletion syndrome and exemplify that the mouse model achieves some part of face validity and predictive validity. Unbiased whole-brain imaging revealed that neuronal hyperactivation after a behavioral task was strikingly exaggerated in a restricted region of the cortex of Df/+ mice. We further elucidated the cellular phenotypes of neuronal hyperactivation and the reduction of parvalbumin expression in the cortex of Df/+ mice. Thus, the 3q29 mouse model provides invaluable insight into the disease-causative molecular and cellular pathology of psychiatric disorders.

Details

Language :
English
ISSN :
1740-634X
Volume :
44
Issue :
12
Database :
MEDLINE
Journal :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Publication Type :
Academic Journal
Accession number :
31216562
Full Text :
https://doi.org/10.1038/s41386-019-0441-5