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A Low-Grade Myxoid Liposarcoma Arising in a Deep-Seated Conventional Lipoma.
- Source :
-
International journal of surgical pathology [Int J Surg Pathol] 2019 Dec; Vol. 27 (8), pp. 919-922. Date of Electronic Publication: 2019 Jun 20. - Publication Year :
- 2019
-
Abstract
- Myxoid liposarcomas (MLS) are known to arise de novo and have not been shown to derive from previous benign lesions (lipomas), whereas lipomas occasionally harbor areas of other benign mesenchymal tissue. Rarely, tumors presenting with MLS or round cell liposarcomas together with conventional liposarcoma have been classified as mixed liposarcomas. However, no case of MLS arising in a conventional lipoma has been described. In this article, we report a case of a young male presenting with a deep-seated soft tissue tumor of the posterior part of the thigh. The tumor was removed en bloc. Grossing revealed a small encapsulated myxoid lesion (2.5 cm) within the larger lipomatous tumor (14 cm). Histological examination and cytogenetic analysis revealed a FUS-CHOP positive low-grade MLS arising in a conventional lipoma without histological atypia, FUS-CHOP fusion, or CDK4/MDM2 amplification. While we cannot conclude whether these were collision tumors or an MLS progression from a lipoma, this case highlights the value of careful grossing in the soft tissue setting.
- Subjects :
- Cyclin-Dependent Kinase 4 genetics
Cytogenetic Analysis
Gene Amplification
Humans
Lipoma genetics
Lipoma pathology
Lipoma surgery
Liposarcoma, Myxoid genetics
Liposarcoma, Myxoid pathology
Liposarcoma, Myxoid surgery
Magnetic Resonance Imaging
Male
Neoplasms, Complex and Mixed genetics
Neoplasms, Complex and Mixed pathology
Neoplasms, Complex and Mixed surgery
Oncogene Proteins, Fusion genetics
Proto-Oncogene Proteins c-mdm2 genetics
RNA-Binding Protein FUS genetics
Subcutaneous Fat diagnostic imaging
Subcutaneous Fat surgery
Thigh
Transcription Factor CHOP genetics
Treatment Outcome
Young Adult
Lipoma diagnosis
Liposarcoma, Myxoid diagnosis
Neoplasms, Complex and Mixed diagnosis
Subcutaneous Fat pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1940-2465
- Volume :
- 27
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 31218893
- Full Text :
- https://doi.org/10.1177/1066896919857147