Back to Search
Start Over
Otitis Media-associated Bacterial Meningitis in Children in a Low-income Country.
- Source :
-
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2019 Aug; Vol. 38 (8), pp. 791-797. - Publication Year :
- 2019
-
Abstract
- Background: Otitis media (OM) is a common childhood infection that may result in bacterial meningitis (BM). However, OM-associated BM remains poorly characterized. We aimed to study the occurrence, clinical presentation and outcome of this type of childhood BM in Luanda, Angola.<br />Methods: Five hundred twelve children from our previous clinical BM trial, with the ear meticulously examined, were analyzed whether they had or not OM, and according to their age, ≤12 month old and >12 month old. Prospectively collected clinical data, laboratory test results and outcome for these groups were assessed.<br />Results: Sixty-two children (12%) had OM-associated BM, of whom 39 had otorrhea. Ear discharge was more common in older children (median age 45 months old vs. 12 months old; P < 0.001). Children with OM often showed an additional infectious focus (n = 20, 32% vs. n = 82, 18%; P = 0.016), were dehydrated (n = 16, 26% vs. n = 66, 15%; P = 0.04), and showed higher odds of complicated clinical course or death (odds ratios 2.27, 95% CI: 1.004-5.15, P = 0.049) compared with children without OM. The >12-month-old children with OM often arrived in poor clinical condition with coma and/or ptosis. Otorrhea was associated with HIV positivity. Infants with otorrhea frequently lived under poor socioeconomic conditions.<br />Conclusions: Children with OM-associated BM were prone to many problems, such as being especially ill at presentation, undergoing a difficult clinical course and showing a higher risk of complicated or fatal outcome. HIV infection and malnutrition were common in children with otorrhea, which was also associated with low socioeconomic status.
- Subjects :
- Adolescent
Angola epidemiology
Child
Child, Preschool
Female
Hospitalization
Humans
Infant
Male
Meningitis, Bacterial diagnosis
Odds Ratio
Otitis Media diagnosis
Patient Outcome Assessment
Poverty
Public Health Surveillance
Socioeconomic Factors
Meningitis, Bacterial epidemiology
Meningitis, Bacterial etiology
Otitis Media complications
Otitis Media epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-0987
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Pediatric infectious disease journal
- Publication Type :
- Academic Journal
- Accession number :
- 31220047
- Full Text :
- https://doi.org/10.1097/INF.0000000000002335