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Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.
- Source :
-
Cardiovascular research [Cardiovasc Res] 2019 Jul 01; Vol. 115 (9), pp. 1385-1392. - Publication Year :
- 2019
-
Abstract
- Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Animals
Arteries metabolism
Arteries physiopathology
Atherosclerosis metabolism
Atherosclerosis physiopathology
Consensus
Humans
Immune System metabolism
Immune System physiopathology
Inflammation metabolism
Inflammation physiopathology
Inflammation Mediators immunology
Inflammation Mediators metabolism
Macrophages immunology
Macrophages metabolism
Monocytes immunology
Monocytes metabolism
Plaque, Atherosclerotic
Signal Transduction
T-Lymphocytes immunology
T-Lymphocytes metabolism
Arteries immunology
Atherosclerosis immunology
Energy Metabolism immunology
Immune System immunology
Immunomodulation
Inflammation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3245
- Volume :
- 115
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cardiovascular research
- Publication Type :
- Academic Journal
- Accession number :
- 31228191
- Full Text :
- https://doi.org/10.1093/cvr/cvz166