A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis.

Authors :: Verma R
Swift BMC
Handley-Hartill W
Lee JK
Woltmann G
Rees CED
Haldar P
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2020 Feb 14; Vol. 70 (5), pp. 933-936.
Publication Year :: 2020
Abstract: The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.<br /> (© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)

Subjects :: Animals
Humans
Bacteremia diagnosis
Bacteriophages
Mycobacterium tuberculosis
Tuberculosis
Tuberculosis, Pulmonary diagnosis

Language :: English
ISSN :: 1537-6591
Volume :: 70
Issue :: 5
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 31233122
Full Text :: https://doi.org/10.1093/cid/ciz548

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