Back to Search
Start Over
NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice.
- Source :
-
Journal of pharmacological sciences [J Pharmacol Sci] 2019 Jun; Vol. 140 (2), pp. 193-196. Date of Electronic Publication: 2019 Feb 21. - Publication Year :
- 2019
-
Abstract
- We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v. before the occlusion, greatly reduced the MCAO/R-induced brain infarct and neurological dysfunctions, although it, given toward the end of occlusion, was less effective. Systemic administration of NNC before the occlusion also attenuated the infarct and neurological dysfunctions. Our data imply that blood-brain-barrier-permeable T-channel blockers such as NNC are capable of reducing MCAO/R-induced brain damage, and that T-channels are involved in neuronal damage induced by ischemia rather than reperfusion.<br /> (Copyright © 2019 The Authors. Production and hosting by Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Benzimidazoles metabolism
Blood-Brain Barrier metabolism
Calcium Channel Blockers metabolism
Calcium Channels, T-Type physiology
Cyclopropanes metabolism
Infusions, Intraventricular
Infusions, Parenteral
Male
Mice, Inbred Strains
Naphthalenes metabolism
Time Factors
Benzimidazoles administration & dosage
Brain Injuries etiology
Brain Injuries prevention & control
Calcium Channel Blockers administration & dosage
Cyclopropanes administration & dosage
Infarction, Middle Cerebral Artery complications
Naphthalenes administration & dosage
Reperfusion Injury complications
Subjects
Details
- Language :
- English
- ISSN :
- 1347-8648
- Volume :
- 140
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31235271
- Full Text :
- https://doi.org/10.1016/j.jphs.2019.02.002