Back to Search
Start Over
Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2019 May 27; Vol. 14, pp. 3893-3909. Date of Electronic Publication: 2019 May 27 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Background: Photothermal and chemotherapy treatment has been frequently studied for cancer therapy; however, chemotherapy is equally toxic to both normal and cancer cells. The clinical application value of most kinds of photothermal transforming agents remains limited, due to their poor degradation and minimal accumulation in tumors. Materials and methods: We reported the synthesis of photothermal transforming agents (MoS <subscript>2</subscript> ) and chemotherapeutic (doxorubicin, DOX) co-loaded electrospun nanofibers using blend electrospinning for the treatment of postoperative tumor recurrence. Results: Under the irradiation of an 808 nm laser, the as-prepared chitosan/polyvinyl alcohol/MoS <subscript>2</subscript> /DOX nanofibers showed an admirable photothermal conversion capability with a photothermal conversion efficiency of 23.2%. These composite nanofibers are in vitro and in vivo biocompatible. In addition, they could control the sustained release of DOX and the generated heat can sensitize the chemotherapeutic efficacy of DOX via enhancing its release rate. Their chemo-/photothermal combined therapy efficiency was systematically studied in vitro and in vivo. Instead of circulating with the body fluid, MoS <subscript>2</subscript> was trapped by the nanofibrous matrix in the tumor and so its tumor-killing ability was not compromised, thus rendering this composite nanofiber a promising alternative for future clinical translation within biomedical application fields. Conclusion: Chitosan/polyvinyl alcohol/MoS <subscript>2</subscript> /DOX nanofibers showed an excellent photothermal conversion capability with a photothermal conversion efficiency of 23.2% and can completely inhibit the postoperative tumor reoccurrence.<br />Competing Interests: The authors report no conflicts of interest in this work.
- Subjects :
- Animals
Biocompatible Materials pharmacology
Cell Death drug effects
Cell Survival drug effects
Cross-Linking Reagents chemistry
Doxorubicin pharmacology
Drug Liberation
HT29 Cells
Humans
Mice, Inbred BALB C
Mice, Nude
Nanofibers ultrastructure
Neoplasm Recurrence, Local pathology
Neoplasms blood
Neoplasms pathology
Neoplasms surgery
Reference Standards
Treatment Outcome
Disulfides chemistry
Doxorubicin therapeutic use
Molybdenum chemistry
Nanofibers chemistry
Nanotechnology methods
Neoplasms therapy
Phototherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 31239663
- Full Text :
- https://doi.org/10.2147/IJN.S202876