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Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.
- Source :
-
Nature communications [Nat Commun] 2019 Jun 28; Vol. 10 (1), pp. 2887. Date of Electronic Publication: 2019 Jun 28. - Publication Year :
- 2019
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Abstract
- Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune signatures are dominated by either IFN-γ and IFN-inducible, IL-17-induced neutrophil- or allergy-associated gene expression. Type I IFN and IFN-γ-inducible, but not IL-17- or allergy-associated signatures, are preserved in the blood. While IL-17-associated genes identified in lung are detected in blood, the allergy signature is only detectable in blood CD4 <superscript>+</superscript> effector cells. Type I IFN-inducible genes are abrogated in the absence of IFN-γ signaling and decrease in the absence of IFNAR signaling, both independently contributing to the regulation of granulocyte responses and pathology during Toxoplasma gondii infection. Our framework provides an ideal tool for comparative analyses of transcriptional signatures contributing to protection or pathogenesis in disease.
- Subjects :
- Animals
Burkholderia pseudomallei
Candida albicans
Candidiasis immunology
Candidiasis microbiology
Gene Expression Regulation immunology
Influenza A Virus, H3N2 Subtype
Interferon Type I blood
Interferon Type I genetics
Interferon-gamma blood
Interferon-gamma genetics
Lung
Melioidosis immunology
Mice
Mice, Inbred C57BL
Orthomyxoviridae Infections genetics
Orthomyxoviridae Infections immunology
Orthomyxoviridae Infections virology
Receptor, Interferon alpha-beta
Receptors, Interferon
Respiratory Syncytial Virus Infections immunology
Interferon gamma Receptor
Candidiasis metabolism
Interferon Type I metabolism
Interferon-gamma metabolism
Melioidosis metabolism
Orthomyxoviridae Infections metabolism
Respiratory Syncytial Virus Infections metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 31253760
- Full Text :
- https://doi.org/10.1038/s41467-019-10601-6