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Induction of resistance in mice by the capsular polysaccharide antigens of Staphylococcus aureus.
- Source :
-
Microbiology and immunology [Microbiol Immunol] 1987; Vol. 31 (7), pp. 649-56. - Publication Year :
- 1987
-
Abstract
- Mice actively immunized with capsular polysaccharides extracted from capsular type strains A, B, C, and D, determined by the serum-soft agar technique, were protected against lethal infection by homologous strains, but no animals survived infection by heterologous substance immunization even with at high doses. Passive protective antibody in rabbit antisera prepared using these strains was absorbed out only by homologous capsular polysaccharide in mice. These results indicated that resistance was specific for capsular polysaccharide. The substance contained mainly neutral sugar, small amounts of hexosamine, methyl-pentose, and phosphate although these amounts varied depending on the capsular types strains.
- Subjects :
- Animals
Female
Galactose analysis
Immunodiffusion
Mice
Mice, Inbred Strains
Polysaccharides, Bacterial analysis
Polysaccharides, Bacterial pharmacology
Rabbits
Species Specificity
Staphylococcus aureus analysis
Staphylococcus aureus immunology
Immunization
Polysaccharides, Bacterial immunology
Staphylococcal Infections prevention & control
Staphylococcal Vaccines
Subjects
Details
- Language :
- English
- ISSN :
- 0385-5600
- Volume :
- 31
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 3125414
- Full Text :
- https://doi.org/10.1111/j.1348-0421.1987.tb03125.x