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Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.
- Source :
-
The New England journal of medicine [N Engl J Med] 2019 Jul 04; Vol. 381 (1), pp. 47-54. - Publication Year :
- 2019
-
Abstract
- A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display. Immunoassays were used to identify KLHL11 IgG in 12 other men with similar neurologic features and testicular disease. Immunostaining of the patient's IgG on mouse brain tissue showed sparse but distinctive points of staining in multiple brain regions, with enrichment in perivascular and perimeningeal tissues. The onset of the neurologic syndrome preceded the diagnosis of seminoma in 9 of the 13 patients. An age-adjusted estimate of the prevalence of autoimmune KLHL11 encephalitis in Olmsted County, Minnesota, was 2.79 cases per 100,000 men. (Funded by the Rochester Epidemiology Project and others.).<br /> (Copyright © 2019 Massachusetts Medical Society.)
- Subjects :
- Adult
Aged
Encephalitis epidemiology
Hashimoto Disease epidemiology
Humans
Immunoassay
Male
Middle Aged
Minnesota epidemiology
Prevalence
Autoantibodies analysis
Brain immunology
Carrier Proteins immunology
Cell Surface Display Techniques
Encephalitis immunology
Hashimoto Disease immunology
Paraneoplastic Syndromes, Nervous System immunology
Seminoma complications
Testicular Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 1533-4406
- Volume :
- 381
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The New England journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31269365
- Full Text :
- https://doi.org/10.1056/NEJMoa1816721