Application of the Balloon Snake in the Volume Measurement of Subretinal Fluid in Central Serous Chorioretinopathy.

Purpose: To apply the Balloon Snake to detect the edge and measure the volume of subretinal fluid (SRF) from spectral domain optical coherence tomography (SD-OCT) images of patients with central serous chorioretinopathy (CSC). Methods: A total of 20 CSC patients whose SD-OCT images collected from their unilateral eyes were enrolled for the study. An image analysis program developed based on the Balloon Snake was used to detect the edge and to measure the volume of SRF. Results: Good agreement was found between the manual segmentation and the Balloon Snake-based method (intraclass correlation coefficient = 0.994). For each volume measurement, the mean time used by the Balloon Snake-based method was 130.5 ± 63.2 (range 54.0 to 227.3) seconds, approximately 30 min faster than the manual segmentation. Conclusion: The Balloon Snake-based method produced accurate and time-efficient volume measurement of SRF in patients with CSC.