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A Polymorphism rs6726395 in Nrf2 Contributes to the Development of Emphysema-Associated Age in Smokers Without COPD.
- Source :
-
Lung [Lung] 2019 Oct; Vol. 197 (5), pp. 559-564. Date of Electronic Publication: 2019 Jul 11. - Publication Year :
- 2019
-
Abstract
- Introduction: Several studies have reported that single nucleotide polymorphisms (SNPs) in the gene encoding NF-E2-related factor 2 (Nrf2) contribute to airflow limitations in smokers without COPD. Although small airway lesions and emphysema contribute cooperatively to airflow limitation, the relationship between Nrf2 SNPs and the development of emphysema in smokers without COPD is not well understood.<br />Methods: Healthy subjects who underwent an annual health checkup with computed tomography (CT) of the chest at Osaka City University Hospital were prospectively recruited. The percentage of low-attenuation area (%LAA) on chest CT was quantified, and correlations between %LAA, Nrf2 SNP [rs6726395 (G/A)] genotypes, and clinical characteristics were examined.<br />Results: A total of 245 subjects without COPD [non-/light-smoker: 153 (62.4%) and smoker: 92 (37.6%)] were enrolled. The %LAA in the upper lung field was higher than that in the lower lung field (p < 0.001). The %LAA in smokers was significantly higher than that in non-/light-smokers (p = 0.021). The %LAA showed significant but weak correlation with age in all subjects (r = 0.141, p = 0.028). Divided by genotype, the %LAA of the upper lung field was significantly correlated with age in smokers with genotype GG (wild type) (r = 0.333, p = 0.022), but was not significantly correlated with age in smokers with genotype AG/AA. These correlations were not observed in non-/light smokers.<br />Conclusion: A polymorphism rs6726395 in Nrf2 can contribute to the development of emphysema-associated aging in smokers. The Nrf2 SNP may be a predictive factor for smoking-induced emphysema, and genotyping of Nrf2 SNP may serve as biomarker for emphysema prevention.
- Subjects :
- Adult
Age Factors
Aged
Female
Genetic Predisposition to Disease
Heterozygote
Homozygote
Humans
Japan
Lung diagnostic imaging
Lung physiopathology
Male
Middle Aged
Non-Smokers
Phenotype
Prospective Studies
Pulmonary Emphysema diagnostic imaging
Pulmonary Emphysema physiopathology
Risk Assessment
Risk Factors
Tomography, X-Ray Computed
NF-E2-Related Factor 2 genetics
Polymorphism, Single Nucleotide
Pulmonary Emphysema genetics
Smokers
Smoking adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1750
- Volume :
- 197
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Lung
- Publication Type :
- Academic Journal
- Accession number :
- 31297601
- Full Text :
- https://doi.org/10.1007/s00408-019-00251-2