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[Updates in systemic sclerosis pathogenesis: Toward new therapeutic opportunities].
- Source :
-
La Revue de medecine interne [Rev Med Interne] 2019 Oct; Vol. 40 (10), pp. 654-663. Date of Electronic Publication: 2019 Jul 11. - Publication Year :
- 2019
-
Abstract
- Systemic sclerosis is a rare connective tissue disease characterized by skin and several internal organ fibrosis, systemic vasculopathy and immune abnormalities. Even if fibroblasts and endothelial cells dysfunction, as well as lymphocytes and other immune cells implication are now well described, the exact origin and chronology of the disease pathogenesis remain unclear. Oxidative stress, influenced by genetic and environmental factors, seems to play a key role. Indeed, it seems to be implicated in the early phases of fibrosis development, vasculopathy and in immune tolerance abnormalities shared by all patients, although disease expression is heterogeneous. To date, no curative treatment is available. Even if immunosuppressive treatment or drugs acting on vascular system are proposed for some patients, overall, treatment efficiency remains modest. Only autologous hematopoietic stem cells transplantation, reserved for patients with severe or rapidly progressive fibrosis, has recently demonstrated efficiency, with lasting regression of fibrosis. Nevertheless, this treatment can expose to important, life-threatening toxicity. In the last decade, new mechanisms implicated in the pathogenesis of systemic sclerosis have been unraveled, bringing new therapeutic opportunities. In this review, we offer to focus on recent insights in the knowledge of systemic sclerosis pathogenesis and its implication in current and future medical care.<br /> (Copyright © 2019 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- B-Lymphocytes immunology
Dysbiosis complications
Endothelial Cells physiology
Endothelium physiopathology
Fibroblasts physiology
Gene-Environment Interaction
Hematopoietic Stem Cell Transplantation adverse effects
Humans
Immune Tolerance
Immunity, Cellular
Immunosuppressive Agents therapeutic use
Oxidative Stress
Risk Factors
Vascular Diseases complications
Vascular Diseases drug therapy
Scleroderma, Systemic etiology
Scleroderma, Systemic therapy
Subjects
Details
- Language :
- French
- ISSN :
- 1768-3122
- Volume :
- 40
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- La Revue de medecine interne
- Publication Type :
- Academic Journal
- Accession number :
- 31301944
- Full Text :
- https://doi.org/10.1016/j.revmed.2019.05.016