Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia.

Authors :: Tarabai H
Valcek A
Jamborova I
Vazhov SV
Karyakin IV
Raab R
Literak I
Dolejska M
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Aug 23; Vol. 63 (9). Date of Electronic Publication: 2019 Aug 23 (Print Publication: 2019).
Publication Year :: 2019
Abstract: The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite ( Milvus migrans ) scavenging raptor. Whole-genome sequencing and plasmid transferability experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp). Migratory black kites may contribute to the global spread of mobile colistin resistance.<br /> (Copyright © 2019 American Society for Microbiology.)

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