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Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC.
- Source :
-
Scientific reports [Sci Rep] 2019 Jul 15; Vol. 9 (1), pp. 10163. Date of Electronic Publication: 2019 Jul 15. - Publication Year :
- 2019
-
Abstract
- Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) were constructed (Norwegian cohort). Immunohistochemistry (IHC) was used to evaluate the expression of PDGFRα and -β in stromal cells and to explore their impact on patient survival. Results were validated in a non-related cohort consisting of TMAs of 367 stage I (A and B) NSCLC patients (Swedish cohort). High stromal PDGFRα expression was an independent predictor of increased survival in the overall populations and SCC (squamous cell carcinoma) subgroups of both investigated cohorts. PDGFRβ was an independent predictor of poor survival in the overall Norwegian cohort and an independent predictor of increased survival in the ADC (adenocarcinoma) subgroup of the Swedish cohort. Tumors displaying the combination PDGFRα-low/PDGFRβ-high exhibited inferior survival according to increasing stage in the Norwegian cohort. This study confirms that high stromal expression of PDGFRα is a predictor of increased survival in NSCLC. Further exploration of the prognostic impact of PDGFRβ and the relationship between PDGFRα and -β is warranted.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung metabolism
Carcinoma, Squamous Cell metabolism
Female
Humans
Immunohistochemistry methods
Lung Neoplasms pathology
Male
Middle Aged
Platelet-Derived Growth Factor metabolism
Prognosis
Receptor, Platelet-Derived Growth Factor alpha metabolism
Receptor, Platelet-Derived Growth Factor beta metabolism
Receptors, Platelet-Derived Growth Factor metabolism
Stromal Cells metabolism
Tissue Array Analysis methods
Carcinoma, Non-Small-Cell Lung genetics
Receptors, Platelet-Derived Growth Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 31308421
- Full Text :
- https://doi.org/10.1038/s41598-019-46510-3