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HIV-2 antisera cross-neutralize HIV-1.

Authors :
Weiss RA
Clapham PR
Weber JN
Whitby D
Tedder RS
O'Connor T
Chamaret S
Montagnier L
Source :
AIDS (London, England) [AIDS] 1988 Apr; Vol. 2 (2), pp. 95-100.
Publication Year :
1988

Abstract

The neutralization properties of three independent HIV-2 isolates were examined in comparison with four diverse HIV-1 strains. Human sera containing antibodies specific to HIV-2 can cross-neutralize HIV-1. By contrast, HIV-1 sera are group-specific and have no neutralizing effect on HIV-2. Therefore, HIV-2 antigens may be important components for the development of broadly cross-protective AIDS vaccines.

Subjects

Subjects :
Antibody Specificity
Cross Reactions
Enzyme-Linked Immunosorbent Assay
HIV Antibodies
Humans
Precipitin Tests
Antibodies, Viral physiology
HIV immunology
Immune Sera pharmacology
Neutralization Tests methods

Details

Language :
English
ISSN :
0269-9370
Volume :
2
Issue :
2
Database :
MEDLINE
Journal :
AIDS (London, England)
Publication Type :
Academic Journal
Accession number :
3132953
Full Text :
https://doi.org/10.1097/00002030-198804000-00004
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