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Effect of bisphenol-A (BPA) on placental biomarkers for inflammation, neurodevelopment and oxidative stress.
- Source :
-
Journal of perinatal medicine [J Perinat Med] 2019 Sep 25; Vol. 47 (7), pp. 741-749. - Publication Year :
- 2019
-
Abstract
- Background Bisphenol-A (BPA) is a widespread pollutant whose effects on pregnant women are poorly understood. Therefore, we investigated the effects of BPA on basal and bacteria-stimulated production of proinflammatory cytokines [interleukin (IL)-1β, tumor necrosis factor-α (TNF-α) and IL-6], anti-inflammatory mediators [soluble glycoprotein 130 (sgp) 130, heme oxidase-1 (HO-1) and IL-10] and biomarkers for neurodevelopment [brain-derived neurotrophic factor (BDNF)], and oxidative stress [8-isoprostane (8-IsoP)] by the placenta. Methods Placental explant cultures were treated with BPA (0-10,000 nM) in the presence or absence of 107 colony-forming unit (CFU)/mL heat-killed Escherichia coli for 24 h. Biomarker concentrations in conditioned medium were quantified by the enzyme-linked immunosorbent assay (ELISA). Results Under basal conditions, IL-1β and IL-6 production was enhanced by BPA in a dose-dependent manner. Sgp130, a soluble receptor that reduces IL-6 bioactivity, was suppressed by BPA at 1000-10,000 nM. BPA also enhanced BDNF production at 1000 and 10,000 nM, and 8-IsoP expression at 10 and 100 nM. For bacteria-treated cultures, BPA increased IL-6 production at 100 nM and reduced sgp130 at 1000 nM but had no effect on IL-1β, TNF-α, BDNF, HO-1, 8-IsoP or IL-10 production. Conclusion BPA may increase placental inflammation by promoting IL-1β and IL-6 but inhibiting sgp130. It may also disrupt oxidative balance and neurodevelopment by increasing 8-IsoP and BDNF production.
- Subjects :
- Air Pollutants, Occupational adverse effects
Air Pollutants, Occupational metabolism
Biomarkers metabolism
Colony Count, Microbial methods
Estrogens, Non-Steroidal adverse effects
Estrogens, Non-Steroidal metabolism
Female
Humans
Oxidative Stress drug effects
Pregnancy
Benzhydryl Compounds adverse effects
Benzhydryl Compounds metabolism
Brain-Derived Neurotrophic Factor metabolism
Cytokines classification
Cytokines metabolism
Escherichia coli growth & development
Inflammation chemically induced
Inflammation metabolism
Phenols adverse effects
Phenols metabolism
Placenta drug effects
Placenta immunology
Placenta metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1619-3997
- Volume :
- 47
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of perinatal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31339859
- Full Text :
- https://doi.org/10.1515/jpm-2019-0045