Mesenchymal stem cells and IL-37: a powerful combination.

Authors :: Gugliandolo A
Caraffa AL
Gallenga CE
Kritas SK
Ronconi G
Trubiani O
Conti P
Di Emidio P
Mazzon E
Source :: Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2019 Jul-Aug; Vol. 33 (4), pp. 1019-1022.
Publication Year :: 2019
Abstract: Mesenchymal stem cells (MSCs) are able to exert immunomodulatory and anti-inflammatory actions. Thanks to these properties, MSCs may be a promising alternative approach for the treatment of inflammatory disease. Important cytokines involved in inflammation are those included in the IL-1 family. Interleukin-37 (IL-37) is one of the member able to suppress both innate and adaptive immunity. Recently, it was found that MSCs and their derivatives can modulate IL-37, and MSCs expressing IL-37 seem to have an enhanced therapeutic efficacy.<br /> (Copyright 2019 Biolife Sas. www.biolifesas.org.)