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Innate lymphoid cells link gut microbes with mucosal T cell immunity.
- Source :
-
Gut microbes [Gut Microbes] 2020; Vol. 11 (2), pp. 231-236. Date of Electronic Publication: 2019 Jul 26. - Publication Year :
- 2020
-
Abstract
- Despite continuous exposure to trillions of microbes, the intestinal immune system protects the mucosa by balancing barrier protection, tolerance, and immunity. As both sentinel and effector, the mucosal innate immune system plays a central role in coordinating these responses. By integrating signals from the intestinal microbiota, mononuclear phagocytes (MNPs) serve as a critical link in regulating effector functions of group 3 innate lymphoid cells (ILC3s). Our recent work identified the role for MNP production of the IBD-linked protein TNF-like ligand 1A (TL1A) in modulating microbial regulation of ILC3 barrier immunity. These findings highlight a broader role for ILC3s in local control of T cell immunity and their potential role in the pathogenesis and treatment of inflammatory disease.
- Subjects :
- Animals
Antimicrobial Cationic Peptides metabolism
Colitis metabolism
Colitis microbiology
Cytokines metabolism
Humans
Immunity, Innate immunology
Inflammatory Bowel Diseases metabolism
Inflammatory Bowel Diseases microbiology
Intestinal Mucosa cytology
Intestinal Mucosa metabolism
Intestinal Mucosa microbiology
OX40 Ligand metabolism
Tumor Necrosis Factor Ligand Superfamily Member 15 metabolism
Gastrointestinal Microbiome immunology
Immunity, Mucosal
Intestinal Mucosa immunology
Intraepithelial Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1949-0984
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gut microbes
- Publication Type :
- Academic Journal
- Accession number :
- 31347946
- Full Text :
- https://doi.org/10.1080/19490976.2019.1638725