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The beneficial effect of traditional Japanese herbal (Kampo) medicine, Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), for patients with chronic wounds refractory to conventional therapies: A prospective, randomized trial.
- Source :
-
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2019 Nov; Vol. 27 (6), pp. 672-679. Date of Electronic Publication: 2019 Aug 09. - Publication Year :
- 2019
-
Abstract
- Hochu-ekki-to (HET) is a traditional Japanese herbal (Kampo) medicine for the treatment of severe weakness, loss of appetite, and indigestion in elderly patients and for the prevention of opportunistic infections. The impact of HET on patients with chronic wounds refractory to conventional therapies was investigated in a prospective, randomized trial, including 18 patients divided into medication (7.5 g oral HET per day, n = 9) and control (n = 9) groups. Wound healing during the 12-week study period was scored based on depth, exudate, size, inflammation/infection, granulation tissue, necrotic tissue, and pocket size. At 12 weeks, wound healing progressed in all nine patients in the medication group, whereas wound healing progressed in only three patients in the control group (significant difference, p < 0.01; relative risk: 3.00). In the medication group, the total score decreased significantly at 8 weeks and later. To the best of our knowledge, this study was the first to show that HET promoted the healing of chronic wounds resistant to conventional treatments. HET may be a choice as an adjunctive therapy for chronic wounds, particularly for patients with malnutrition. This trial was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000031620).<br /> (© 2019 by the Wound Healing Society.)
- Subjects :
- Administration, Oral
Adult
Aged
Chronic Disease
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Foot Ulcer diagnosis
Foot Ulcer drug therapy
Humans
Japan
Male
Middle Aged
Patient Selection
Pressure Ulcer diagnosis
Pressure Ulcer drug therapy
Prospective Studies
Reference Values
Treatment Outcome
Wound Healing physiology
Wounds and Injuries diagnosis
Drugs, Chinese Herbal administration & dosage
Medicine, Kampo methods
Wound Healing drug effects
Wounds and Injuries drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1524-475X
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
- Publication Type :
- Academic Journal
- Accession number :
- 31350938
- Full Text :
- https://doi.org/10.1111/wrr.12753