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Nasal thallium-201 uptake in patients with parosmia with and without hyposmia after upper respiratory tract infection.
- Source :
-
International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2019 Nov; Vol. 9 (11), pp. 1252-1256. Date of Electronic Publication: 2019 Jul 29. - Publication Year :
- 2019
-
Abstract
- Background: In this study, we aimed to determine whether nasal thallium-201 uptake of the olfactory cleft and olfactory bulb (OB) differs between patients with parosmia with and without hyposmia after upper respiratory tract infection (URTI).<br />Methods: Twenty patients with parosmia after URTI were enrolled in this study (15 women and 5 men, 28 to 76 years old). Nasally administered thallium-201 migration to the OB, nasal thallium-201 uptake ratio in the olfactory cleft, and OB volume were determined in 10 patients with normal T&T olfactometry (Daiichi Yakuhin Sangyo, Tokyo, Japan) odor recognition thresholds (≤2.0) who still complained of parosmia (parosmia group), and 10 patients with T&T odor recognition thresholds >2.0 (parosmia and hyposmia group).<br />Results: The nasal thallium-201 uptake ratio in the olfactory cleft was significantly higher in the parosmia group than in the parosmia and hyposmia group (p = 0.0015). Thallium-201 migration to the OB was not significantly different between the 2 groups (p = 0.31). The OB volume was significantly larger in the parosmia group than that in the parosmia and hyposmia group (p = 0.029); however, the mean OB volume in both the groups was lower than the normal threshold value in healthy individuals.<br />Conclusion: Our results signify the recovery of the olfactory epithelium; however, the olfactory neural projections to the OB and regeneration of OB were not complete in patients with parosmia with normal T&T recognition thresholds after URTI.<br /> (© 2019 The Authors. International Forum of Allergy & Rhinology by Wiley Periodicals, Inc. on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.)
- Subjects :
- Adult
Aged
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Olfactory Bulb pathology
Olfactory Nerve pathology
Radionuclide Imaging
Smell
Olfaction Disorders diagnosis
Olfactometry methods
Olfactory Bulb diagnostic imaging
Olfactory Nerve diagnostic imaging
Respiratory Tract Infections diagnosis
Thallium Radioisotopes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2042-6984
- Volume :
- 9
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International forum of allergy & rhinology
- Publication Type :
- Academic Journal
- Accession number :
- 31356735
- Full Text :
- https://doi.org/10.1002/alr.22395