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Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease.
- Source :
-
Behavioural brain research [Behav Brain Res] 2019 Nov 18; Vol. 374, pp. 112106. Date of Electronic Publication: 2019 Jul 26. - Publication Year :
- 2019
-
Abstract
- Neuroinflammation and insulin resistance in the brain are intimately linked to neurodegenerative disorders, including Alzheimer's disease. Even though traditionally Alzheimer´s disease has been associated to Aβ deposits and hyperphosphorylated Tau intracellular tangles, several studies show that neuroinflammation may be the initial cause that triggers degeneration. Accordingly, a number of natural supplements that improves brain insulin sensitivity and reduce neuroinflammation have been proposed as good choices in the therapeutic prevention of cognitive decline. Further supporting this evidence, we show that phytohormone Abscisic Acid, can prevent memory impairment and neuroinflammation markers in a triple transgenic mouse model, where no peripheral inflammatory changes have occurred. Moreover, our data strongly suggests that early intervention is critical for good prognosis, and that cognitive improvement requires longer treatment than recovering neuroinflammation markers.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Abscisic Acid metabolism
Alzheimer Disease genetics
Alzheimer Disease physiopathology
Amyloid beta-Peptides metabolism
Amyloid beta-Protein Precursor genetics
Animals
Brain metabolism
Cerebral Cortex metabolism
Cognitive Dysfunction drug therapy
Disease Models, Animal
Hippocampus metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neuroimmunomodulation physiology
Neuroprotective Agents therapeutic use
Plaque, Amyloid metabolism
tau Proteins metabolism
Abscisic Acid pharmacology
Alzheimer Disease drug therapy
Memory Disorders drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 374
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 31356828
- Full Text :
- https://doi.org/10.1016/j.bbr.2019.112106