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[Osteoporosis and chronic kidney disease: review and new therapeutic strategies].

Authors :
Sessa C
Galeano D
Alessandrello I
Aprile G
Distefano G
Ficara V
Giglio E
Musumeci S
Pocorobba B
Zuppardo C
Musso S
Granata A
Source :
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2019 Jul 24; Vol. 36 (4). Date of Electronic Publication: 2019 Jul 24.
Publication Year :
2019

Abstract

Osteoporosis affects a segment of the population in which Chronic Kidney Disease is also greatly represented. Nephropathic patients may present peculiar biochemical abnormalities related to Chronic Kidney Disease, defining the Mineral and Bone Disorder. This kind of anomalies, in the worst scenarios, configure the typical histomorphology patterns of Renal Osteodystrophy. Scientific Societies of Endocrinology have established therapy guidelines for patients with osteoporosis only based on the glomerular filtration rate and recommend avoiding the use of some drugs for the more advanced classes of nephropathy. However, there is no clear therapeutic approach for patients with advanced nephropathy and bone abnormalities. In this paper we propose a systematic review of the literature and present our proposal for managing patients with advanced nephropathy, based on eGFR and on presence of Mineral and Bone Disorder.<br /> (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.)

Details

Language :
Italian
ISSN :
1724-5990
Volume :
36
Issue :
4
Database :
MEDLINE
Journal :
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia
Publication Type :
Academic Journal
Accession number :
31373465