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Production and regulation of tumor necrosis factor alpha. A cellular and molecular analysis.
- Source :
-
Methods and achievements in experimental pathology [Methods Achiev Exp Pathol] 1988; Vol. 13, pp. 240-59. - Publication Year :
- 1988
-
Abstract
- Tumor necrosis factor alpha is increasingly being recognized as an important macrophage-derived cytokine that possesses pleomorphic effects in both physiologic and immunologic systems. Current evidence has demonstrated that tumor necrosis factor may stimulate a plethora of cellular responses in vitro and induce multiple physiologic derangements when given in vivo. While the biologic activity of tumor necrosis factor elaborated by macrophages and macrophage cell lines in response to bacterial and protozoal cell products have been well documented, the endogenous factors that regulate the production of this monokine are not as clearly delineated. This chapter focuses on the cellular and molecular mechanisms that endogenously regulate the production of tumor necrosis factor.
- Subjects :
- 6-Ketoprostaglandin F1 alpha biosynthesis
Animals
Arachidonic Acid
Arachidonic Acids metabolism
Cells, Cultured
Dinoprostone
Epoprostenol physiology
Indomethacin pharmacology
Lipopolysaccharides pharmacology
Macrophages metabolism
Mice
Prostaglandins E biosynthesis
Prostaglandins E physiology
Radioimmunoassay
Tumor Necrosis Factor-alpha analysis
Tumor Necrosis Factor-alpha biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0076-681X
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Methods and achievements in experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 3137425