[Efficacy of conventional chemotherapy in a primary double-refractory IgM multiple myeloma.]

We report the case of a young man and good PS, diagnosed with a stage II A Durie-Salmon, II ISS and II Revised-ISS IgM kappa Multiple Myeloma. After refractoriety to the I and II-line induction therapies, including novel and novel novel agents, we decided to treat the patient with conventional high dose chemotherapy, with dexamethasone, cyclophosphamide, etoposide and cisplatin (DCEP), achieving a very good partial response (VGPR). Furthermore, we discuss histopathologic patterns, to make a correct differential diagnosis with others IgM-correlated disorders. Analyzing the literature, we demonstrated that more intensive therapy correlates with better therapeutic goals, therefore, empathizing that today IgM Multiple Myeloma is still a difficult pathological subtype to treat.