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A pair of novel bisindole alkaloid enantiomers from marine fungus Fusarium sp. XBB-9.
- Source :
-
Natural product research [Nat Prod Res] 2021 May; Vol. 35 (9), pp. 1497-1503. Date of Electronic Publication: 2019 Aug 22. - Publication Year :
- 2021
-
Abstract
- A preliminary research on the marine fungus Fusarium sp. XBB-9 resulted in a pair of novel bisindole alkaloid enantiomers, (+)- and (-)-fusaspoid A ( 1a / 1b ) and 12 diverse compounds. One strain many compound (OSMAC) method was used to enhance as many biosynthetic pathways as possible. The structures of the compounds were elucidated by spectroscopic analysis, and the absolute configuration of 1a was determined by X-ray single-crystal diffraction analysis. Compounds 1a and 1b were tested for cytotoxic activity against HCT-15, RKO cell lines, but were inactive. Compounds 1a and 1b were the first example of bisindole alkaloids isolated from fungus Fusarium sp. XBB-9.
- Subjects :
- Antineoplastic Agents pharmacology
Carbon-13 Magnetic Resonance Spectroscopy
Cell Death drug effects
Cell Line, Tumor
Crystallography, X-Ray
Humans
Indole Alkaloids pharmacology
Models, Molecular
Proton Magnetic Resonance Spectroscopy
Stereoisomerism
Aquatic Organisms chemistry
Fusarium chemistry
Indole Alkaloids chemistry
Indole Alkaloids isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 35
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 31437009
- Full Text :
- https://doi.org/10.1080/14786419.2019.1655416