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The inhibitory effect of quaternary ammonium salt on bacteria in root canal.
- Source :
-
Scientific reports [Sci Rep] 2019 Aug 28; Vol. 9 (1), pp. 12463. Date of Electronic Publication: 2019 Aug 28. - Publication Year :
- 2019
-
Abstract
- Persisting apical periodontitis is a primary reason for multiple intervention in root canal. Persisting bacteria in root canal is related with the persisting infection. Despite the advancement in treatment strategies the persisting infection is a major challenge for endodontist. Here we tested two newly developed quaternary ammonium methacrylates (QAMs) against endodontic bacteria and their biofilms. Their antibacterial and antibiofilm efficiency were compared with chlorhexidine (CHX) and sodium hypochlorite (NaOCl). We measured the MIC, MBC and MBIC of DMADDM and DMAHDM respectively. We also detected the ratio of live/dead bacteria and bacterial composition in the biofilms treated by DMADDM and DMAHDM. We found that DMADDM and DMAHDM could inhibit the growth of bacteria and biofilms formation. The result showed that novel QAMs were remarkably efficient than CHX against biofilms. In addition, we found that Streptococcus gordonii (S. gordonii) and Enterococcus faecalis (E. faecalis) were frequent isolates after treatment with antimicrobial compounds.
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Biofilms growth & development
Dental Pulp Cavity microbiology
Humans
Biofilms drug effects
Enterococcus faecalis physiology
Methacrylates chemistry
Methacrylates pharmacology
Quaternary Ammonium Compounds chemistry
Quaternary Ammonium Compounds pharmacology
Root Canal Therapy
Streptococcus gordonii physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 31462657
- Full Text :
- https://doi.org/10.1038/s41598-019-48666-4