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The gut microbiome and cardiovascular disease: current knowledge and clinical potential.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2019 Nov 01; Vol. 317 (5), pp. H923-H938. Date of Electronic Publication: 2019 Aug 30. - Publication Year :
- 2019
-
Abstract
- Cardiovascular disease (CVD) is the leading cause of death worldwide. The human body is populated by a diverse community of microbes, dominated by bacteria, but also including viruses and fungi. The largest and most complex of these communities is located in the gastrointestinal system and, with its associated genome, is known as the gut microbiome. Gut microbiome perturbations and related dysbiosis have been implicated in the progression and pathogenesis of CVD, including atherosclerosis, hypertension, and heart failure. Although there have been advances in the characterization and analysis of the gut microbiota and associated bacterial metabolites, the exact mechanisms through which they exert their action are not well understood. This review will focus on the role of the gut microbiome and associated functional components in the development and progression of atherosclerosis. Potential treatments to alter the gut microbiome to prevent or treat atherosclerosis and CVD are also discussed.
- Subjects :
- Animals
Anti-Bacterial Agents therapeutic use
Arteries metabolism
Arteries pathology
Atherosclerosis metabolism
Atherosclerosis pathology
Atherosclerosis therapy
Diet, Healthy
Dietary Supplements
Dysbiosis
Fecal Microbiota Transplantation
Host-Pathogen Interactions
Humans
Plaque, Atherosclerotic
Signal Transduction
Arteries microbiology
Atherosclerosis microbiology
Bacteria metabolism
Gastrointestinal Microbiome
Intestines microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1539
- Volume :
- 317
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 31469291
- Full Text :
- https://doi.org/10.1152/ajpheart.00376.2019