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Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline.
- Source :
-
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Sep 01; Vol. 200 (5), pp. 535-550. - Publication Year :
- 2019
-
Abstract
- Background: Fungal infections are of increasing incidence and importance in immunocompromised and immunocompetent patients. Timely diagnosis relies on appropriate use of laboratory testing in susceptible patients. Methods: The relevant literature related to diagnosis of invasive pulmonary aspergillosis, invasive candidiasis, and the common endemic mycoses was systematically reviewed. Meta-analysis was performed when appropriate. Recommendations were developed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Results: This guideline includes specific recommendations on the use of galactomannan testing in serum and BAL and for the diagnosis of invasive pulmonary aspergillosis, the role of PCR in the diagnosis of invasive pulmonary aspergillosis, the role of β-d-glucan assays in the diagnosis of invasive candidiasis, and the application of serology and antigen testing in the diagnosis of the endemic mycoses. Conclusions: Rapid, accurate diagnosis of fungal infections relies on appropriate application of laboratory testing, including antigen testing, serological testing, and PCR-based assays.
- Subjects :
- Humans
Galactose analogs & derivatives
Mannans
Serology methods
Societies, Medical
United States
Candidiasis, Invasive diagnosis
Candidiasis, Invasive immunology
Critical Care standards
Invasive Pulmonary Aspergillosis diagnosis
Invasive Pulmonary Aspergillosis immunology
Polymerase Chain Reaction methods
Subjects
Details
- Language :
- English
- ISSN :
- 1535-4970
- Volume :
- 200
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of respiratory and critical care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31469325
- Full Text :
- https://doi.org/10.1164/rccm.201906-1185ST